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Wednesday, June 27, 2012

Benefits of postoperative Chemotherapy

Benefits of postoperative Chemotherapy on Elderly person with lung cancer
Administering chemotherapy adjuvan in patients of lung cancer types rather than small cell stage IB-III (non-small cell lung cancer, NSCLC) visible increase relapse-free and overall survival in several clinical trials. However, the median age of patients in clinical trials that have ranged from 59 to 61 years of age. Not yet known for sure if the patient was also benefit further against the granting of postoperative chemotherapy (adjuvan therapy).

To answer these questions, conducted observational cohort study involving patients with NSCLC stage II 3324-aged ≥ 65 years IIIA of the Surveillance Epidemiology and End Results (SEER) database 1992-2005. As much as 21% (n = 684) of these patients received a platinum-based chemotherapy post-war operations. An analysis of preliminary data showed no difference in demographic factors among patients who received chemotherapy with who received no chemotherapy.

Observed an increase in life expectancy in patients stadium II and IIIA who got the chemotherapy (hazard ratio 0.80; 95% CI,-0.90 0.72). Detailed chemotherapy regimen is not assessed. Age stratification based on analysis shows that the benefits of increased life expectancy was only observed in patients aged category < 70 years and 70 – 79 years of age, but not in patients aged ≥ 80 years. Insidens hospitalization due to serious side effects at higher in patients who received chemotherapy compared to 13.0% not (vs. 6.9%) with odds ratio 2.0 (95% CI, 1.5-2.6). The benefits of giving chemotherapy also observed in patients who received radiotherapy and radiotherapy do not get.

In conclusion, the adjuvan platinum-based chemotherapy was associated with a decrease in mortality and an increase in serious adverse effects on the person with disability-IIIA NSCLC stage II. The magnitude of the benefits comparable to that observed in randomized clinical trials.
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