If there’s one thing we know about mesothelioma treatment, it’s this: we’re still being challenged to arrive at efficacy.
Despite years of research since the disease was first identified, it’s still difficult to identify the best approach to treating the disease, says David Rice, MD, a cardiothoracic surgeon and nationally known mesothelioma expert who practices at the University of Texas MD Anderson Cancer Center in Houston, TX.
The very rareness of the cancer—only about 3,000 people a year are diagnosed in the United States—makes it difficult to run the kind of research studies needed to compare treatments and determine the ideal therapy at each stage of the disease. “There isn’t a lot of evidence-based science in this disease,” Dr. Rice admits. So when his patients ask him what the best treatment is for the disease, he tells them what we tell you in this section, adding that “we don’t have a reliable cure for this disease.”
Thus, a major goal of treatment is to reduce pain and suffering and prolong a patient’s life as long as possible while providing them with the highest quality of life possible.
Choosing the right mesothelioma doctor is an important first step in planning for treatment.
There are a number of mesothelioma experts, like Dr. Rice, practicing in specialized clinics throughout the country. Each of these cancer specialists has an acute knowledge of the behavior and pathology of malignant mesothelioma and its treatment. It is likely that if you are diagnosed with mesothelioma, you will be referred by your personal physician to a larger scale comprehensive cancer center.
The most important consideration in mesothelioma treatment is the cancer stage and type, said Dr. Rice. Treatment decisions also depend on whether the cancer is localized to the chest or has spread to the chest wall, diaphragm, or lymph nodes, your age and overall health, and the center where you’re being treated. Learn more about finding a doctor here.
Conventional treatments for mesothelioma involve surgery, chemotherapy, and radiation therapy.
As with most solid tumors, doctors turn to surgery, radiation and chemotherapy to manage mesothelioma. When exploring the various treatment options available with your doctor it is important to be informed about the risk and benefits of each one before making a final decision.
Surgery
Only about 1 in 5 patients with metastatic pleural mesothelioma undergo surgery. There are two main surgeries: pleurectomy/decortication, in which the surgeon tries to remove as much of the tumor from around the lung as possible, and the more radical extrapleural pneumonectomy, in which the lung itself is removed.
There is a lot of debate as to which is “best,” said Dr. Rice, although studies find that most long-term survivors have had surgery. He personally believes that pneumonectomy is best for tumor control if followed with radiation. Studies find it prevents tumor recurrence in the chest in 80 to 85 percent of patients who have the surgery.
However, Dr. Rice noted, it is a long, intensive operation with a 55 percent complication rate and a 3 percent risk of death, higher in some institutions. “So you only want to perform that surgery if the patient has a reasonably good prognosis,” said Dr. Rice. Translation: it doesn’t appear that the cancer has spread outside the chest.
Patients best suited for pneumonectomy are younger, with the epithelial form of the disease, no obvious lymph gland involvement, and are otherwise healthy enough to withstand the rigor of the procedure. Dr. Rice actually waits until he has the patient’s chest open in the operating room and biopsies the lymph nodes before deciding which procedure to perform.
Pleurectomy/decortication has a higher failure rate, with the tumor recurring in the chest cavity 50 to 80 percent of the time. However, that rate may change with improved radiotherapy techniques, Dr. Rice said. The reason for the high recurrence is that it’s impossible to completely remove the tumor without removing the lung.
However, he noted, there is no difference in survival rates between the two surgeries. Part of the reason is that the cancer has often spread to other parts of the body by the time it is diagnosed even if it appears to be confined to the chest.
Chemotherapy
Chemotherapy, also known as systemic therapy, uses oral or infusion-based medications to kill cancer cells throughout your body. Chemotherapy is used both before and after surgery, as well as in people who can’t handle surgery. It is also used in the palliative setting to reduce pain and improve quality of life.
The most commonly used chemotherapy drugs for mesothelioma are cisplatin combined with pemetrexed (Alimta) or raltitrexed (Tomudex). Other combinations include gemcitabine, carboplatin or oxaliplatin.
If you can’t manage combination therapy, your doctor may start on just one drug. Sometimes, your doctor may infuse the medication directly into your chest cavity, a procedure called pleural chemotherapy, or, abdomen, called intraperitoneal chemotherapy. You may also get a second course of chemotherapy, called “second-line” chemotherapy, with pemetrexed or other drugs, raltitrexed plus oxaliplatin, or the triple drug combination of irinotecan, cisplatin and mitomycin.
Some centers are beginning to provide intraperitoneal chemotherapy before surgery, followed by chemotherapy shortly after surgery. You can learn more about this approach here. There is also work underway to personalize chemotherapy based on the genetic characteristics of your tumor.
Radiation
Radiation can be an important part of mesothelioma treatment. The problem is that because the cancer is near the heart and lungs, it’s challenging to provide the kind of high-dose, intensive therapy needed to shrink the tumor. However, a newer option, intensity-modulated radiotherapy (IMRT), which can more accurately target cancer cells and avoid healthy tissue, may provide better results when performed by experienced clinicians.
Investigational therapies are being explored through clinical and surgical trials at many of the nation’s top cancer centers.
There are more than 50 studies on new therapies for mesothelioma in the U.S. that are looking for volunteers. Researchers are investigating new targeted drugs and chemotherapies, as well as new protocols for giving the medications; immunotherapy, which harnesses the power of the immune system to fight the disease; phototherapy, in which you are injected with a drug that bonds to cancer cells and is activated by high-intensity light; genetic therapies; and novel radiotherapy techniques like tomotherapy to treat the disease. Learn more about participating in a clinical trial here.
At some point, the management of the disease will shift from trying to cure the disease to trying to keep the patient as comfortable as possible for as long as possible.
This is the palliative care stage, when many people enter a hospice program. The primary goal at this stage is maximizing patient comfort. Medication to help with pain, difficulty breathing, and other symptoms that may be experienced is a mainstay. So is emotional and spiritual support for you and your family.
Alternative therapies for mesothelioma can be used to ease side effects of traditional cancer treatment.
Complementary and alternative medicine (CAM) includes such therapies as massage, acupuncture, and meditation. They can be a powerful part of your overall management plan, helping you better manage the stress and anxiety of the disease and conventional treatments.
Source : http://www.mesothelioma.com/treatment/
Showing posts with label Mesothelioma. Show all posts
Showing posts with label Mesothelioma. Show all posts
Friday, March 2, 2012
Thursday, February 2, 2012
Asbestos Exposure and how it can be
Many American workers, across a variety of industries, were exposed to asbestos on the job. As a result, they are now at risk to develop mesothelioma.
Long considered a miracle material, asbestos boasts excellent fire and heat resistant properties. This naturally occurring mineral, now known to be a human carcinogen, has a history that dates back to ancient Greece. Asbestos was used as a building material, even as far back as during the Roman Empire, and was also used to in fabric that would be used in clothing and a variety of other textiles.
During the Industrial Revolution, asbestos found new uses in factories and other heavy industries throughout the United States and abroad. Asbestos found use not only in factories, but also in oil refineries, chemical plants, on railroad cars, and in shipyards. Asbestos materials were used to insulate pipes and boilers in steam locomotives, to line tanks and ovens in refineries, and could be found literally everywhere aboard the nation’s ships, from engine rooms to galleys. As the twentieth century progressed, more uses for asbestos were found. It was used in the brakes and clutches of automobiles, insulated America’s new skyscrapers, and was used extensively in the construction industry, where it was used in asbestos products like joint compounds, cements, roofing shingles, ceiling and floor tiles, siding, stucco, plaster, and much more. Those workers at risk included any that worked in an asbestos-heavy industry or frequently handled these products.
By the middle of the twentieth century, it became apparent that asbestos was causing health problems. Asbestos exposure is now known to cause mesothelioma. This asbestos related cancer can occur when asbestos is inhaled the microscopic fibers lodge within the outer lung tissue layer known as the mesothelium. This thin layer of cells protects and lubricates the chest cavity. Asbestos causes a sustained inflammation of these cells causing harmful scar tissue to form on the surface. This scar tissue lays the foundation for cancerous cells to develop.
Despite knowledge of the health risk it posed, records have shown that many companies who used asbestos in their facilities knew that the material was dangerous yet continued to allow its use. Eventually, stories of sick employees became commonplace, causing the American government to consider imposing laws about regulating use of asbestos.
If you worked at a jobsite where asbestos or asbestos containing products were used, you may be at risk to develop mesothelioma.
Exposure usually occurred at major construction jobsites, in shipyards, onboard navy vessels and during construction or renovation of commercial buildings. People working in the vicinity of boilers and insulated piping often are at risk. In addition, teachers, students, and other staff members who work in older school buildings may be at risk of exposure to asbestos products, such as ceiling or floor tiles. Equally at risk are families of these workers, as asbestos often was carried home on clothing.
Military Exposure
Asbestos was used across all branches of the military for many years. Navy veterans were exposed to high levels of asbestos while serving on ships (aircraft carriers, destroyers, submarines, battleships, warships, etc.) in the naval fleet as well as in naval shipyards across the country. Army veterans were exposed to asbestos in buildings on military installations and while working on military vehicles. Air Force veterans were exposed while working with military aircraft. Marine Corps veterans that spent time at sea aboard Navy ships were exposed to asbestos. All veterans exposed to asbestos have an increased risk of developing mesothelioma.
Commercial and Industrial Exposure
Many workers and maintenance contractors at industrial and commercial job sites were subjected to dangerous levels of asbestos on the job. Asbestos is a known carcinogen and the primary cause of mesothelioma cancer. The types of jobsites where asbestos exposure occurred include oil refineries, power plants, steel mills and chemical plants to name a few. They all have “high heat” environments where the use of fire and heat resistant materials was required, be it in the construction of the plants or machinery or in the protective clothing that workers were required to wear in designated areas (i.e. fire-proof gloves and aprons). Today, even though the use of asbestos has been banned in the United States, many existing industrial and commercial structures may still contain a certain level of asbestos. It is important that appropriate safety precautions be taken, where necessary, to prevent harmful exposure and to mitigate the risk of developing mesothelioma.
Commercial Product Exposure
Do-it-yourself home renovation enthusiasts, as well as those who worked in the construction trade, may have been exposed to asbestos while working with popular building and construction products. Many of these products were made with asbestos through the late 1970’s as the projects they were to be used in required that they be heat and fire resistant. They included insulation, roofing material, siding, joint compound, ceiling tiles, flooring and more. Unfortunately when any of these products were cut, sawed filed, or sanded, asbestos fibers were released into the air. In the majority of cases, those working with the products did not use appropriate safety precautions because asbestos companies withheld information about the health hazards of asbestos for many years. Today, as a result, construction workers and do-it-yourselfers are at risk for developing mesothelioma or other asbestos-related diseases.
Second Hand Exposure
Direct, on-the-job asbestos exposure did not affect American workers alone. Their family members were also at risk of developing an asbestos-related disease as a result of second hand asbestos exposure. This type of exposure occurred when workers brought asbestos fibers home on their hair, clothing or shoes at the end of the work day. Those responsible for laundering their work clothes, day in and day out, were most commonly affected, but even small children who spent time with their parent before they had a chance to “clean up” from work were unknowingly placed at risk of developing an asbestos-related illness.
Source : http://www.mesothelioma.com/asbestos-exposure/
Long considered a miracle material, asbestos boasts excellent fire and heat resistant properties. This naturally occurring mineral, now known to be a human carcinogen, has a history that dates back to ancient Greece. Asbestos was used as a building material, even as far back as during the Roman Empire, and was also used to in fabric that would be used in clothing and a variety of other textiles.
During the Industrial Revolution, asbestos found new uses in factories and other heavy industries throughout the United States and abroad. Asbestos found use not only in factories, but also in oil refineries, chemical plants, on railroad cars, and in shipyards. Asbestos materials were used to insulate pipes and boilers in steam locomotives, to line tanks and ovens in refineries, and could be found literally everywhere aboard the nation’s ships, from engine rooms to galleys. As the twentieth century progressed, more uses for asbestos were found. It was used in the brakes and clutches of automobiles, insulated America’s new skyscrapers, and was used extensively in the construction industry, where it was used in asbestos products like joint compounds, cements, roofing shingles, ceiling and floor tiles, siding, stucco, plaster, and much more. Those workers at risk included any that worked in an asbestos-heavy industry or frequently handled these products.
By the middle of the twentieth century, it became apparent that asbestos was causing health problems. Asbestos exposure is now known to cause mesothelioma. This asbestos related cancer can occur when asbestos is inhaled the microscopic fibers lodge within the outer lung tissue layer known as the mesothelium. This thin layer of cells protects and lubricates the chest cavity. Asbestos causes a sustained inflammation of these cells causing harmful scar tissue to form on the surface. This scar tissue lays the foundation for cancerous cells to develop.
Despite knowledge of the health risk it posed, records have shown that many companies who used asbestos in their facilities knew that the material was dangerous yet continued to allow its use. Eventually, stories of sick employees became commonplace, causing the American government to consider imposing laws about regulating use of asbestos.
If you worked at a jobsite where asbestos or asbestos containing products were used, you may be at risk to develop mesothelioma.
Exposure usually occurred at major construction jobsites, in shipyards, onboard navy vessels and during construction or renovation of commercial buildings. People working in the vicinity of boilers and insulated piping often are at risk. In addition, teachers, students, and other staff members who work in older school buildings may be at risk of exposure to asbestos products, such as ceiling or floor tiles. Equally at risk are families of these workers, as asbestos often was carried home on clothing.
Military Exposure
Asbestos was used across all branches of the military for many years. Navy veterans were exposed to high levels of asbestos while serving on ships (aircraft carriers, destroyers, submarines, battleships, warships, etc.) in the naval fleet as well as in naval shipyards across the country. Army veterans were exposed to asbestos in buildings on military installations and while working on military vehicles. Air Force veterans were exposed while working with military aircraft. Marine Corps veterans that spent time at sea aboard Navy ships were exposed to asbestos. All veterans exposed to asbestos have an increased risk of developing mesothelioma.
Commercial and Industrial Exposure
Many workers and maintenance contractors at industrial and commercial job sites were subjected to dangerous levels of asbestos on the job. Asbestos is a known carcinogen and the primary cause of mesothelioma cancer. The types of jobsites where asbestos exposure occurred include oil refineries, power plants, steel mills and chemical plants to name a few. They all have “high heat” environments where the use of fire and heat resistant materials was required, be it in the construction of the plants or machinery or in the protective clothing that workers were required to wear in designated areas (i.e. fire-proof gloves and aprons). Today, even though the use of asbestos has been banned in the United States, many existing industrial and commercial structures may still contain a certain level of asbestos. It is important that appropriate safety precautions be taken, where necessary, to prevent harmful exposure and to mitigate the risk of developing mesothelioma.
Commercial Product Exposure
Do-it-yourself home renovation enthusiasts, as well as those who worked in the construction trade, may have been exposed to asbestos while working with popular building and construction products. Many of these products were made with asbestos through the late 1970’s as the projects they were to be used in required that they be heat and fire resistant. They included insulation, roofing material, siding, joint compound, ceiling tiles, flooring and more. Unfortunately when any of these products were cut, sawed filed, or sanded, asbestos fibers were released into the air. In the majority of cases, those working with the products did not use appropriate safety precautions because asbestos companies withheld information about the health hazards of asbestos for many years. Today, as a result, construction workers and do-it-yourselfers are at risk for developing mesothelioma or other asbestos-related diseases.
Second Hand Exposure
Direct, on-the-job asbestos exposure did not affect American workers alone. Their family members were also at risk of developing an asbestos-related disease as a result of second hand asbestos exposure. This type of exposure occurred when workers brought asbestos fibers home on their hair, clothing or shoes at the end of the work day. Those responsible for laundering their work clothes, day in and day out, were most commonly affected, but even small children who spent time with their parent before they had a chance to “clean up” from work were unknowingly placed at risk of developing an asbestos-related illness.
Source : http://www.mesothelioma.com/asbestos-exposure/
Wednesday, October 12, 2011
Mesothelioma Cancer
Mesothelioma is an aggressive cancer affecting the membrane lining of the lungs and abdomen.
Malignant mesothelioma is the most serious of all asbestos-related diseases. Although uncommon, mesothelioma cancer is no longer considered rare. The primary cause and risk factor for mesothelioma is exposure to asbestos.
Making a correct mesothelioma diagnosis is particularly difficult for doctors because the disease often presents with symptoms that mimic other common ailments. There is no known cure for mesothelioma, but treatments such as surgery and chemotherapy have helped to improve the typical mesothelioma prognosis.
Pleural mesothelioma (affecting the lung’s protective lining in the chest cavity) represents about three quarters of all mesothelioma incidence. Peritoneal mesothelioma which affects the abdominal cavity and pericardial mesothelioma, which affects the cardiac cavity, comprise the remainder. Testicular mesothelioma is extremely rare and is typically presents with metastases of the peritoneal variety. There are three recognized mesothelioma cell-types. Between 50 and 70% of all mesotheliomas are of the epithelial variety. While prognosis is generally poor, it is considered less aggressive than sarcomatoid mesothelioma and biphasic mesothelioma, which comprise the remainder of cell type diagnoses.
The cavities within the body encompassing the chest, abdomen, and heart are surround by a membrane of cells known as the mesothelium. Mesothelial cells assist in general organ functions. The mesothelium is particularly important to organs that are commonly in motion, such as expansion or contraction of the lungs, stomach, or heart. Lubrication from the mesothelial cells allows free range of motion within the body. The mesothelium of the chest, abdomen, and cardiac cavity are called the pleura, the peritoneum, and the pericardium, respectively. Each of these groupings of mesothelial cells are extremely critical to the functions of the body structures which they encompass.
Malignancies (cancerous tumors) occurring within the mesothelial membranes are known as malignant mesothelioma, or simply mesothelioma. Benign tumors of the mesothelium are known to occur, but are much rarer than the more common malignant cancer.
While tumors of the mesothelium were first recognized in the late 18th century, it was not until the middle of the 20th century that this particular cancer was studied and examined with more detail. It was at this time where suspicions of the cancer’s causal relationship with asbestos exposure became more substantiated. A joint research venture through the Department of Thoracic Surgery at the University of the Witswater and/Johannesburg General Hospital in South Africa provided the most compelling evidence of the nexus between asbestos exposure and the development of pleural mesothelioma.
Incidence of mesothelioma is still quite rare, with only 2,500-3000 diagnoses in the United States each year. There was a spike in reported diagnoses between 1970 and 1984, which has been attributed to the latency period between diagnosis and the height of industrial exposures, which occurred roughly 40-60 years prior to this time. Exposure was common in nearly all industries but was particularly common in the WWII-era military industrial cycle, including Navy Shipyards.
Although this cancer is much more common in men over the age of 60 (largely attributed to the industrial exposures within male-dominated industries), mesothelioma in women and children has been described as well. Mesothelioma causes for diagnosis in women and children are mainly attributed to secondary exposure to asbestos, as it was not uncommon for men to bring asbestos back into the home on their body or clothing if proper cleaning facilities were not available on site.
Mesothelioma is diagnosed through a comprehensive combination of biopsy and imaging scans.
Mesothelioma can be a difficult malignancy to diagnose because the symptoms and pathology of the disease closely resemble other respiratory conditions. For this reason, misdiagnosis is not uncommon in mesothelioma patients. Symptoms of mesothelioma include chest pain, chronic cough, effusions of the chest and abdomen, and the presence of blood in lung fluid.
Diagnostic surgeries, including a biopsy, will typically be required to determine the type of malignant cells that are present in the body. Typically a body imaging scan, including a magnetic resonance image (MRI) or computer topography (CT scan) will be required to determine the extent and location of the disease.
Mesothelioma patients are generally referred by their personal physicians to one of the many renowned mesothelioma doctors in the United States. These oncologists are well versed in the disease behavior and pathology and are the most familiar with cutting-edge mesothelioma treatment options. Dr. David Sugarbaker of the Brigham and Women's Hospital, an extension of Harvard University and the Dana Farber Cancer Institute in Boston, MA, is at the forefront of mesothelioma treatment through the International Mesothelioma Program.
While mesothelioma is typically advanced at diagnosis, treatment options are available.
Mesothelioma, while certainly an aggressive disease, is a manageable malignancy. While there is no cure for the cancer, mesothelioma treatment options including surgery, chemotherapy, and radiation therapy are available for many patients. While a combination of Alimta® and Cisplatin is currently the only FDA approved chemotherapy regimen, several clinical trials are currently in progress utilizing other drugs including Gemcitabine and Onconase, with many showing dramatically improved results in certain cancer patients.
Radiation therapy is also utilized, but typically in conjunction with other treatment methods like surgery and chemotherapy. Surgical resection of mesothelioma is possible in early-stage-diagnosed patients. Aggressive surgeries such as extrapleural pneumonectomy can extend survival rates far beyond previously-thought timeframes. Diagnostic and palliative surgeries such as pleurocentesis and pleurodesis are also common in patients of malignant mesothelioma cancer.
Alternative therapies have also been used effectively by many mesothelioma patients to assist in managing symptoms of the disease and conventional treatments. These treatments are mainly preferential but can be extremely valuable to many patients.
Mesothelioma is caused by exposure to asbestos.
Mesothelioma is only caused by exposure to asbestos, though cases have been documented in children or other individuals with no asbestos history. Asbestos is a microscopic and naturally-occurring mineral that lodges in the pleural lining of the lungs and the peritoneal lining of the abdominal cavity. In most cases, several years will pass (up to 60) before mesothelioma develops in those who had been exposed to asbestos.
In many cases, those individuals diagnosed with mesothelioma that have been known to be exposed to asbestos may be eligible for financial compensation from asbestos manufacturers for their illness. Those who have been diagnosed with mesothelioma and were exposed to asbestos should fill out the brief form on this page. We'll rush you a complimentary mesothelioma and asbestos exposure information kit detailing new mesothelioma treatments, active clinical trials, top doctors, as well as how to obtain compensation for asbestos-related health conditions like mesothelioma.
Malignant mesothelioma is the most serious of all asbestos-related diseases. Although uncommon, mesothelioma cancer is no longer considered rare. The primary cause and risk factor for mesothelioma is exposure to asbestos.
Making a correct mesothelioma diagnosis is particularly difficult for doctors because the disease often presents with symptoms that mimic other common ailments. There is no known cure for mesothelioma, but treatments such as surgery and chemotherapy have helped to improve the typical mesothelioma prognosis.
Pleural mesothelioma (affecting the lung’s protective lining in the chest cavity) represents about three quarters of all mesothelioma incidence. Peritoneal mesothelioma which affects the abdominal cavity and pericardial mesothelioma, which affects the cardiac cavity, comprise the remainder. Testicular mesothelioma is extremely rare and is typically presents with metastases of the peritoneal variety. There are three recognized mesothelioma cell-types. Between 50 and 70% of all mesotheliomas are of the epithelial variety. While prognosis is generally poor, it is considered less aggressive than sarcomatoid mesothelioma and biphasic mesothelioma, which comprise the remainder of cell type diagnoses.
The cavities within the body encompassing the chest, abdomen, and heart are surround by a membrane of cells known as the mesothelium. Mesothelial cells assist in general organ functions. The mesothelium is particularly important to organs that are commonly in motion, such as expansion or contraction of the lungs, stomach, or heart. Lubrication from the mesothelial cells allows free range of motion within the body. The mesothelium of the chest, abdomen, and cardiac cavity are called the pleura, the peritoneum, and the pericardium, respectively. Each of these groupings of mesothelial cells are extremely critical to the functions of the body structures which they encompass.
Malignancies (cancerous tumors) occurring within the mesothelial membranes are known as malignant mesothelioma, or simply mesothelioma. Benign tumors of the mesothelium are known to occur, but are much rarer than the more common malignant cancer.
While tumors of the mesothelium were first recognized in the late 18th century, it was not until the middle of the 20th century that this particular cancer was studied and examined with more detail. It was at this time where suspicions of the cancer’s causal relationship with asbestos exposure became more substantiated. A joint research venture through the Department of Thoracic Surgery at the University of the Witswater and/Johannesburg General Hospital in South Africa provided the most compelling evidence of the nexus between asbestos exposure and the development of pleural mesothelioma.
Incidence of mesothelioma is still quite rare, with only 2,500-3000 diagnoses in the United States each year. There was a spike in reported diagnoses between 1970 and 1984, which has been attributed to the latency period between diagnosis and the height of industrial exposures, which occurred roughly 40-60 years prior to this time. Exposure was common in nearly all industries but was particularly common in the WWII-era military industrial cycle, including Navy Shipyards.
Although this cancer is much more common in men over the age of 60 (largely attributed to the industrial exposures within male-dominated industries), mesothelioma in women and children has been described as well. Mesothelioma causes for diagnosis in women and children are mainly attributed to secondary exposure to asbestos, as it was not uncommon for men to bring asbestos back into the home on their body or clothing if proper cleaning facilities were not available on site.
Mesothelioma is diagnosed through a comprehensive combination of biopsy and imaging scans.
Mesothelioma can be a difficult malignancy to diagnose because the symptoms and pathology of the disease closely resemble other respiratory conditions. For this reason, misdiagnosis is not uncommon in mesothelioma patients. Symptoms of mesothelioma include chest pain, chronic cough, effusions of the chest and abdomen, and the presence of blood in lung fluid.
Diagnostic surgeries, including a biopsy, will typically be required to determine the type of malignant cells that are present in the body. Typically a body imaging scan, including a magnetic resonance image (MRI) or computer topography (CT scan) will be required to determine the extent and location of the disease.
Mesothelioma patients are generally referred by their personal physicians to one of the many renowned mesothelioma doctors in the United States. These oncologists are well versed in the disease behavior and pathology and are the most familiar with cutting-edge mesothelioma treatment options. Dr. David Sugarbaker of the Brigham and Women's Hospital, an extension of Harvard University and the Dana Farber Cancer Institute in Boston, MA, is at the forefront of mesothelioma treatment through the International Mesothelioma Program.
While mesothelioma is typically advanced at diagnosis, treatment options are available.
Mesothelioma, while certainly an aggressive disease, is a manageable malignancy. While there is no cure for the cancer, mesothelioma treatment options including surgery, chemotherapy, and radiation therapy are available for many patients. While a combination of Alimta® and Cisplatin is currently the only FDA approved chemotherapy regimen, several clinical trials are currently in progress utilizing other drugs including Gemcitabine and Onconase, with many showing dramatically improved results in certain cancer patients.
Radiation therapy is also utilized, but typically in conjunction with other treatment methods like surgery and chemotherapy. Surgical resection of mesothelioma is possible in early-stage-diagnosed patients. Aggressive surgeries such as extrapleural pneumonectomy can extend survival rates far beyond previously-thought timeframes. Diagnostic and palliative surgeries such as pleurocentesis and pleurodesis are also common in patients of malignant mesothelioma cancer.
Alternative therapies have also been used effectively by many mesothelioma patients to assist in managing symptoms of the disease and conventional treatments. These treatments are mainly preferential but can be extremely valuable to many patients.
Mesothelioma is caused by exposure to asbestos.
Mesothelioma is only caused by exposure to asbestos, though cases have been documented in children or other individuals with no asbestos history. Asbestos is a microscopic and naturally-occurring mineral that lodges in the pleural lining of the lungs and the peritoneal lining of the abdominal cavity. In most cases, several years will pass (up to 60) before mesothelioma develops in those who had been exposed to asbestos.
In many cases, those individuals diagnosed with mesothelioma that have been known to be exposed to asbestos may be eligible for financial compensation from asbestos manufacturers for their illness. Those who have been diagnosed with mesothelioma and were exposed to asbestos should fill out the brief form on this page. We'll rush you a complimentary mesothelioma and asbestos exposure information kit detailing new mesothelioma treatments, active clinical trials, top doctors, as well as how to obtain compensation for asbestos-related health conditions like mesothelioma.
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